Bioavailability of curcumin: problems and promises
Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Molecular Pharmacology 2007, 4(6):807-18
Bioavailability!
- Is it a problem?
- Combine with piperine
- Nanoparticles
- Liposomal curcumin
- Synthetic analogues
Bioavailability! Is it a problem?
Tissue distribution of curcumin administered systemically
Curcumin uptake in rat
Marczylo TH, Steward WP, Gescher AJ. Rapid analysis of curcumin and curcumin metabolites in rat biomatrices using a novel ultraperformance liquid chromatography (UPLC) method. J Agric Food Chem. 2009, 57(3):797-803
Tissue distribution of curcumin administered IP/orally
Piperine increases the bioavailability of curcumin by inhibiting glucuronidation
Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Planta Medica 1998, 64(4):353-6
Major metabolites of curcumin in rodents and humans
Sharma RA, Gescher AJ, Steward WP. Curcumin: the story so far. Eur J Cancer. 2005, 41(13):1955-68
Piperine increases the bioavailability of curcumin in human
Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007, 4(6):807-18
Polymeric nanoparticle-encapsulated curcumin ("nano curcumin"): a novel strategy for human cancer therapy
Bisht S, Feldmann G, Soni S, Ravi R, Karikar C, Maitra A. Journal of Nanobiotechnology 2007, 17: 5:3
Nonocurcumin has higher cellular uptake than curcumin
Conclusions!
- Most diseases including cancer is due to dysregulation of multiple genes.
- Mono-targeted drugs are unlikely to be an effective therapy.
- Multi-targeted drugs are needed
- Most natural products are designed for multi-targeting
Conclusion! Inflammation is an Ideal Target to Discover Therapeutics for Prevention and Treatment of Cancer
