Publications

Online Sources

  1. Darvesh AS, Aggarwal BB, Bishayee A. (2011) "Curcumin and Liver Cancer: A Review." Curr Pharm Biotechnol. Apr 5

  2. Reuter, S., S. Eifes, et al. (2008). "Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells." Biochem Pharmacol 76(11): 1340-51.

  3. Kunnumakkara, A. B., P. Anand, et al. (2008). "Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins." Cancer Lett 269(2): 199-225.

  4. Goel, A., A. B. Kunnumakkara, et al. (2008). "Curcumin as 'Curecumin': from kitchen to clinic." Biochem Pharmacol 75(4): 787-809.

  5. Goel, A., S. Jhurani, et al. (2008). "Multi-targeted therapy by curcumin: how spicy is it?" Mol Nutr Food Res 52(9): 1010-30.

  6. Dhillon, N., B. B. Aggarwal, et al. (2008). "Phase II trial of curcumin in patients with advanced pancreatic cancer." Clin Cancer Res 14(14): 4491-9.

  7. Sandur, S. K., M. K. Pandey, et al. (2007). "Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism." Carcinogenesis 28(8): 1765-73.

  8. Lin, Y. G., A. B. Kunnumakkara, et al. (2007). "Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-κB pathway." Clin Cancer Res 13(11): 3423-30.

  9. Kunnumakkara, A. B., S. Guha, et al. (2007). "Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-κB-regulated gene products." Cancer Res 67(8): 3853-61.

  10. Kamat, A. M., G. Sethi, et al. (2007). "Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-κB and nuclear factor-κB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells." Mol Cancer Ther 6(3): 1022-30.

  11. Aoki, H., Y. Takada, et al. (2007). "Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways." Mol Pharmacol 72(1): 29-39.

  12. Zambre, A. P., V. M. Kulkarni, et al. (2006). "Novel curcumin analogs targeting TNF-induced NF-κB activation and proliferation in human leukemic KBM-5 cells." Bioorg Med Chem 14(21): 7196-204.

  13. Yan, C., M. S. Jamaluddin, et al. (2005). "Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin." Mol Cancer Ther 4(2): 233-41.

  14. Siwak, D. R., S. Shishodia, et al. (2005). "Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IκB kinase and nuclear factor κB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway." Cancer 104(4): 879-90.

  15. Bharti, A. C., Y. Takada, et al. (2005). "PARP cleavage and caspase activity to assess chemosensitivity." Methods Mol Med 111: 69-78.

  16. Aggarwal, B. B., S. Shishodia, et al. (2005). "Curcumin suppresses the paclitaxel-induced nuclear factor-κB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice." Clin Cancer Res 11(20): 7490-8.

  17. Yan, C., H. Wang, et al. (2004). "A novel homologous recombination system to study 92 kDa type IV collagenase transcription demonstrates that the NF-κB motif drives the transition from a repressed to an activated state of gene expression." Faseb J 18(3): 540-1.

  18. Takada, Y., A. Bhardwaj, et al. (2004). "Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-κB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation." Oncogene 23(57): 9247-58.

  19. Li, L., B. B. Aggarwal, et al. (2004). "Nuclear factor-κB and IκB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis." Cancer 101(10): 2351-62.

  20. Bharti, A. C., S. Shishodia, et al. (2004). "Nuclear factor-κB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis." Blood 103(8): 3175-84.

  21. Bharti, A. C., Y. Takada, et al. (2004). "Curcumin (diferuloylmethane) inhibits receptor activator of NF-κ B ligand-induced NF-κ B activation in osteoclast precursors and suppresses osteoclastogenesis." J Immunol 172(10): 5940-7.

  22. Aggarwal, S., Y. Takada, et al. (2004). "Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-κB signaling." Int J Cancer 111(5): 679-92.

  23. Shishodia, S., P. Potdar, et al. (2003). "Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-κB activation through inhibition of IκBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1." Carcinogenesis 24(7): 1269-79.

  24. Bharti, A. C., N. Donato, et al. (2003). "Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-κ B and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis." Blood 101(3): 1053-62.

  25. Mukhopadhyay, A., S. Banerjee, et al. (2002). "Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation." Oncogene 21(57): 8852-61.

  26. Anto, R. J., A. Mukhopadhyay, et al. (2002). "Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl." Carcinogenesis 23(1): 143-50.

  27. Mukhopadhyay, A., C. Bueso-Ramos, et al. (2001). "Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines." Oncogene 20(52): 7597-609.

  28. Singh, S. and B. B. Aggarwal (1995). "Activation of transcription factor NF-κB is suppressed by curcumin (diferuloylmethane) [corrected]." J Biol Chem 270(42): 24995-5000.

  29. Reddy, S. and B. B. Aggarwal (1994). "Curcumin is a non-competitive and selective inhibitor of phosphorylase kinase." FEBS Lett 341(1): 19-22.

PDFs

  1. Prakobwong S, Gupta SC, Kim JH, Sung B, Pinlaor P, Hiraku Y, Wongkham S, Sripa B, Pinlaor S, Aggarwal BB. Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways. Carcinogenesis. 2011 Jul 20.

  2. Reuter S, Gupta SC, Park B, Goel A, Aggarwal BB. Epigenetic changes induced by curcumin and other natural compounds. Genes Nutr. 2011 May;6(2):93-108.

  3. Yadav V.R. and B.B. Aggarwal Curcumin: A Component of The Golden Spice, targets multiple angiogenic pathways. Cancer Biology & Therapy. 2011, 11(2).

  4. Goel, A. and B.B. Aggarwal, Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. Nutrition and cancer, 2010, 62(7): p.919-30.

  5. Yadav VR, Prasad S, Kannappan R, Ravindran J, Chaturvedi MM, Vaahtera L, Parkkinen J, Aggarwal BB. Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake. Biochem Pharmacol. 2010 Oct 1;80(7):1021-32.

  6. Zhang C, Li B, Zhang X, Hazarika P, Aggarwal BB, Duvic M. Curcumin selectively induces apoptosis in cutaneous T-cell lymphoma cell lines and patients' PBMCs:potential role for STAT-3 and NF-kappaB signaling. J Invest Dermatol. 2010 Aug;130(8):2110-9.

  7. Aggarwal BB. Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annu Rev Nutr. 2010 Aug 21;30:173-99.

  8. Anand P, Nair HB, Sung B, Kunnumakkara AB, Yadav VR, Tekmal RR, Aggarwal BB. Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. Biochem Pharmacol. 2010 Feb 1;79(3):330-8.

  9. Jayaraj Ravindran a,1, Gottumukkala V. Subbaraju b, Modukuri V. Ramani b, Bokyung Sung a, Bharat B. Aggarwal. Bisdemethylcurcumin and structurally related hispolon analogues of curcumin exhibit enhanced prooxidant, anti-proliferative and anti-inflammatory activities in vitro. Biochemical Pharmacology 79 (2010) 1658–1666. Jan. 2010

  10. Tharakan ST, Inamoto T, Sung B, Aggarwal BB, Kamat AM. Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers. Biochem Pharmacol. 2010 Jan 15;79(2):218-28.

  11. Kamat AM, Tharakan ST, Sung B, Aggarwal BB. Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer through the downregulation of NF-kappaB and upregulation of TRAIL receptors. Cancer Res. 2009 Dec 1;69(23):8958-66.

  12. Moghaddam SJ, Barta P, Mirabolfathinejad SG, Ammar-Aouchiche Z, Garza NT, Vo TT, Newman RA, Aggarwal BB, Evans CM, Tuvim MJ, Lotan R, Dickey BF. Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice. Carcinogenesis. 2009 Nov;30(11):1949-56.

  13. Dhillon, N., B. Sung, B. B. Aggarwal, and R. Kurzrock Could antitumor Activity of curcumin in patients be due to its metabolites? A response. Clinical Cancer research, 2009, 15(22): p. 7108.

  14. Kunnumakkara AB, Diagaradjane P, Anand P, Kuzhuvelil HB, Deorukhkar A, Gelovani J, Guha S, Krishnan S, Aggarwal BB. Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model. Int J Cancer. 2009 Nov 1;125(9):2187-97.

  15. Sandur SK, Deorukhkar A, Pandey MK, Pabón AM, Shentu S, Guha S, Aggarwal BB, Krishnan S. Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activity. Int J Radiat Oncol Biol Phys. 2009 Oct 1;75(2):534-42.

  16. Supachai Yodkeeree a,c, Chadarat Ampasavate b, Bokyung Sung c, Bharat B. Aggarwal c, Pornngarm Limtrakul. Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line. European Journal of Pharmacology 627 (2010) 8–15. Sep. 2009

  17. Ravindran J, Prasad S, Aggarwal BB. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? AAPS J. 2009 Sep;11(3):495-510.

  18. Ralhan R, Pandey MK, Aggarwal BB. Nuclear factor-κ B links carcinogenic and chemopreventive agents. Front Biosci (Schol Ed). 2009 Jun 1;1:45-60.

  19. Kunnumakkara, A. B., Guha, S., and Aggarwal, B. B. (2009). "Curcumin and Colorectal Cancer: Add Spice to Your Life." Current Colorectal Cancer Reports. Jan. 2009, Vol 5, No. 1: 5-14.

  20. Aggarwal, B. B. and K. B. Harikumar (2009). "Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases." Int J Biochem Cell Biol 41(1): 40-59.

  21. Aggarwal, B. B. and B. Sung (2009). "Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets." Trends Pharmacol Sci 30(2): 85-94.

  22. Reuter, S., M. Schnekenburger, et al. (2009). "Tumor necrosis factor α induces γ-glutamyltransferase expression via nuclear factor-κB in cooperation with Sp1." Biochem Pharmacol 77(3): 397-411.

  23. Gupta V, Aseh A, Ríos CN, Aggarwal BB, Mathur AB. Fabrication and characterization of silk fibroin-derived curcumin nanoparticles for cancer therapy. Int J Nanomedicine. 2009;4:115-22.

  24. Goel, A., S. Jhurani, et al. (2008). "Multi-targeted therapy by curcumin: how spicy is it?" Mol Nutr Food Res 52(9): 1010-30.

  25. Aggarwal, B. B., A. B. Kunnumakkara, et al. (2008). "Potential of spice-derived phytochemicals for cancer prevention." Planta Med 74(13): 1560-9.

  26. Aggarwal, B. B. (2008). "Prostate cancer and curcumin: add spice to your life." Cancer Biol Ther 7(9): 1436-40.

  27. Anand, P., C. Sundaram, et al. (2008). "Curcumin and cancer: an "old-age" disease with an "age-old" solution." Cancer Lett 267(1): 133-64.

  28. Anand, P., S. G. Thomas, et al. (2008). "Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature." Biochem Pharmacol 76(11): 1590-611.

  29. Kunnumakkara, A. B., P. Diagaradjane, et al. (2008). "Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-κB-regulated gene products." Clin Cancer Res 14(7): 2128-36.

  30. Anand, P., A. B. Kunnumakkara, et al. (2007). "Bioavailability of curcumin: problems and promises." Mol Pharm 4(6): 807-18.

  31. Aggarwal, B. B., S. Banerjee, et al. (2007). "Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines." Biochem Pharmacol 73(7): 1024-32.

  32. Jagetia, G. C. and B. B. Aggarwal (2007). ""Spicing up" of the immune system by curcumin." J Clin Immunol 27(1): 19-35.

  33. Khanna, D., G. Sethi, et al. (2007). "Natural products as a gold mine for arthritis treatment." Curr Opin Pharmacol 7(3): 344-51.

  34. Sandur, S. K., H. Ichikawa, et al. (2007). "Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane)." Free Radic Biol Med 43(4): 568-80.

  35. Shishodia, S., M. M. Chaturvedi, et al. (2007). "Role of curcumin in cancer therapy." Curr Probl Cancer 31(4): 243-305.

  36. Aggarwal, B. B., C. Sundaram, et al. (2007). "Curcumin: the Indian solid gold." Adv Exp Med Biol 595: 1-75.

  37. Sharma, C., J. Kaur, et al. (2006). "Curcumin down regulates smokeless tobacco-induced NF-κB activation and COX-2 expression in human oral premalignant and cancer cells." Toxicology 228(1): 1-15.

  38. Aggarwal, B. B. and S. Shishodia (2006). "Molecular targets of dietary agents for prevention and therapy of cancer." Biochem Pharmacol 71(10): 1397-421.

  39. Aggarwal, S., H. Ichikawa, et al. (2006). "Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IκBα kinase and Akt activation." Mol Pharmacol 69(1): 195-206.

  40. Zambre, A. P., V. M. Kulkarni, et al. (2006). "Novel curcumin analogs targeting TNF-induced NF-κB activation and proliferation in human leukemic KBM-5 cells." Bioorg Med Chem 14(21): 7196-204.

  41. Chakravarti, N., J. N. Myers, et al. (2006). "Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane)." Int J Cancer 119(6): 1268-75.

  42. Aggarwal, B. B., G. Sethi, et al. (2006). "Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution." Ann N Y Acad Sci 1091: 151-69.

  43. Garg, A. K., T. A. Buchholz, et al. (2005). "Chemosensitization and radiosensitization of tumors by plant polyphenols." Antioxid Redox Signal 7(11-12): 1630-47.

  44. Shishodia, S., G. Sethi, et al. (2005). "Curcumin: getting back to the roots." Ann N Y Acad Sci 1056: 206-17.

  45. Shishodia, S., H. M. Amin, et al. (2005). "Curcumin (diferuloylmethane) inhibits constitutive NF-κB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma." Biochem Pharmacol 70(5): 700-13.

  46. Aggarwal, B. B., Y. Takada, et al. (2004). "From chemoprevention to chemotherapy: common targets and common goals." Expert Opin Investig Drugs 13(10): 1327-38.

  47. Dorai, T. and B. B. Aggarwal (2004). "Role of chemopreventive agents in cancer therapy." Cancer Lett 215(2): 129-40.

  48. Aggarwal, B. B. and S. Shishodia (2004). "Suppression of the nuclear factor-κB activation pathway by spice-derived phytochemicals: reasoning for seasoning." Ann N Y Acad Sci 1030: 434-41.

  49. Bharti, A. C., N. Donato, et al. (2003). "Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells." J Immunol 171(7): 3863-71.

  50. Aggarwal, B. B., A. Kumar, et al. (2003). "Anticancer potential of curcumin: preclinical and clinical studies." Anticancer Res 23(1A): 363-98.

  51. Kumar, A., S. Dhawan, et al. (1998). "Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-κB activation." Biochem Pharmacol 55(6): 775-83.

  52. Mehta, K., P. Pantazis, et al. (1997). "Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines." Anticancer Drugs 8(5): 470-81.